Invitrogen™ ULK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA522173

Catalog No. PIPA522173

Description

Recommended positive controls: 293T, A431, HeLa, HepG2, NT2D1, NIH-3T3. Predicted reactivity: Mouse (94%), Rat (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

ULK2, also known as ATG1B, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK2 results in a severe defect in the autophagy pathway. ULK2 is highly conserved among eukaryotes and shows high homology with its related protein ULK1. Both ULK1 and ULK2 form a complex with ATG13 and FIP200 that mediates TOR signaling and is essential for autophagy. Like ULK1, ULK2 is also thought to be involved in early neuronal growth and differentiation.

Specifications

• Antigen: ULK2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ULK2
• Gene Alias: A830085I22Rik; ATG1B; AU015340; EC:2.7.11.1; KIAA0623; mKIAA0623; serine/threonine-protein kinase ULK2; Serine/threonine-protein kinase Unc51.2; ULK2; unc-51 like autophagy activating kinase 2; unc-51 like kinase 2; Unc51.2; unc-51-like kinase 2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29869, 9706
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.24 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q8IYT8, Q9QY01
• Gene Symbols: ULK2
• Immunogen: Recombinant fragment corresponding to a region within amino acids 693 and 968 of ULK2 (Uniprot ID#Q8IYT8).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG