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Invitrogen™ UNC5B Polyclonal Antibody
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Catalog No. PIPA547038
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100 μg
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PIPA547038 100 μg
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Catalog No. PIPA547038 Supplier Invitrogen™ Supplier No. PA547038
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Description

Goat Polyclonal Antibody

In direct ELISAs, less than 5% cross-reactivity with recombinant human (rh) UNC5H3 and recombinant rat UNC5H1 is observed, and less than 1% cross-reactivity with rhUNC5H4 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UNC5B
Applications Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene UNC5B
Gene Accession No. O08722
Gene Alias 6330415E02Rik; A630020F16; C. elegans; D10Bwg0792e; Netrin receptor UNC5B; p53RDL1; p53-regulated receptor for death and life protein 1; Protein unc-5 homolog 2; protein unc-5 homolog B; transmembrane receptor Unc5H2; unc5 homolog 2; unc-5 homolog 2; unc-5 homolog B; unc-5 homolog B (C. elegans); unc-5 netrin receptor B; Unc5b; UNC5H2; UNQ1883/PRO4326
Gene Symbols UNC5B
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant rat UNC5H2 Gly27-Asp373.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 60630
Target Species Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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