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Invitrogen™ UNG Polyclonal Antibody
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Catalog No. 01676638
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100 μg
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Catalog No. Quantity
01-676-638 100 μg
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Catalog No. 01-676-638 Supplier Invitrogen™ Supplier No. PA141024
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Description

Rabbit Polyclonal Antibody

This sequence also corresponds to residues 290-307 of human UNG2. Suggested positive control: antigen standard for UNG (transient overexpression lysate), Hela whole cell extract. Expected to cross-react with Chimpanzee, Dog, Zebrafish, Xenopus and Chicken. Immunogen sequence: CRHFSKTNEL LQKSGKKP.

The human UNG gene encodes both nuclear (UNG2) and mitochondrial (UNG1) forms of uracil-DNA glycosylase. These forms are generated by alternative splicing and the use of two differentially regulated promoters, PA and PB. The cDNAs for UNG1 and UNG2 are of similar size (2061 and 2058 bp, respectively) and as a result the corresponding mRNAs are not resolved as two species in gel electrophoresis. Nuclear UNG2 differs from mitochondrial UNG1 in 44 amino acids of the N-terminal sequence that is not necessary for catalytic activity. A major role of the UNG gene products is to repair mutagenic U:G mispairs caused by cytosine deamination. For example, UNG2 removes misincorporated dUMP residues. The level and expression pattern of UNG1 and UNG2 differs between cell and tissue type. Additionally, the expression of UNG is cell cycle regulated. The expression and activity of UNG has been found in general to be higher in proliferating as compared to nonproliferating tissues and cells. UNG1 is a 304 amino acid protein. UNG2 is a 313 amino acid protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UNG
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene Ung
Gene Accession No. P13051, P97931
Gene Alias DGU; DKFZp781L1143; HIGM4; HIGM5; UDG; UNG; Ung1; UNG15; UNG2; unga; uracil DNA glycosylase; uracil DNA glycosylase a; uracil-DNA glycosylase; uracil-DNA glycosylase 1, uracil-DNA glycosylase 2; uracil-DNA glycosylase isoform UNG1; uracil-DNA glycosylase isoform UNG2; uracil-DNA glycosylase nuclear isoform; zgc:56102
Gene Symbols Ung
Host Species Rabbit
Immunogen Synthetic peptide sequence corresponding to amino acids 281-298 of human UNG1 and amino acids 290-307 of human UNG2.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100338366, 22256, 304577, 7374
Target Species Human, Mouse, Rat, Rabbit
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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WARNING: Cancer - www.P65Warnings.ca.gov
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