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Tocris Bioscience™ Upadacitinib
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Catalog No. 778350
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77-835-0 50 mg
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Catalog No. 77-835-0 Supplier Tocris Bioscience™ Supplier No. 7783/50
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Description

JAK1-selective inhibitor

Upadacitinib is a potent and selective JAK1 inhibitor (IC50 = 47 nM). In a cellular assay, Upadacitinib shows selectivity for JAK1 over JAK2, JAK3 and TYK2 (IC50 values are 0.014 μM, 0.593 μM, 1860 μM and 2715 μM). In vivo, Upadacitinib suppresses paw swelling and bone destruction in a rat model of arthritis.

Specifications

Chemical Name or Material (3 S,4 R)-3-Ethyl-4-(3 H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide
CAS 1310726-60-3
Quantity 50 mg
Target Jak1
Molecular Formula C17H19F3N6O
Purity 0.98
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