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Urokinase Monoclonal Antibody (PGM2001), Invitrogen™

Catalog No. 01672345
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200 μg
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Catalog No. Quantity
01-672-345 200 μg
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Catalog No. 01-672-345 Supplier Thermo Scientific Supplier No. MA135844

Description

Mouse Monoclonal Antibody

Reconstitute with 1 mL of distilled water and add preservative if preferred.

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Urokinase
Applications ELISA, Immunohistochemistry (Frozen), Radioimmune Assays (RIA), Western Blot
Classification Monoclonal
Clone PGM2001
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation antibody with no preservative
Gene PLAU
Gene Accession No. P00749
Gene Alias antagonist of uPA; ATF; BDPLT5; CD87; HGNC:9052; plasminogen activator; plasminogen activator, urinary; plasminogen activator, urokinase; Plau; QPD; uPA; u-PA; UPAM; UPAR; U-plasminogen activator; Urinary plasminogen activator, urokinase; URK; URKR; Urokinase-type plasminogen activator; Urokinase-type plasminogen activator chain B; Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A
Gene Symbols PLAU
Host Species Mouse
Immunogen Human urinary urokinase
Purification Method Ion-exchange chromatography, PEG precipitation
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5328
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Lyophilized
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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