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Tocris Bioscience™ Urolithin A
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Catalog No. 676210
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Catalog No. Quantity
67-621-0 10 mg
67-625-0 50 mg
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Description

PI 3-K/Akt/mTOR signaling pathway inhibitor; blocks phosphorylation of Akt and p70S6K in pancreatic ductal adenocarcinoma (PDAC)

Urolithin A is a PI 3-K/Akt/mTOR signaling pathway inhibitor; blocks phosphorylation of Akt and p70S6K in pancreatic ductal adenocarcinoma (PDAC). Inhibits proliferation and migration and promotes apoptosis of PDAC cell lines in vitro (IC50 values are 10.23 - 62.28 μM). Suppresses tumor growth and improves survival in mice bearing pancreatic tumor xenografts. Also blocks amyloid-β fibrillation in vitro.

Specifications

Chemical Name or Material 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one
CAS 1143-70-0
Quantity 10 mg
Molecular Formula C13H8O4
Formula Weight 228.2
Purity 98%
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