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Invitrogen™ Uromodulin Polyclonal Antibody
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Catalog No. PIPA547706
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100 μg
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PIPA547706 100 μg
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Catalog No. PIPA547706 Supplier Invitrogen™ Supplier No. PA547706
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Description

Sheep Polyclonal Antibody

In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human Uromodulin is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Uromodulin
Applications Immunohistochemistry (Frozen), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Umod
Gene Accession No. Q91X17
Gene Alias ADMCKD2; FJHN; HNFJ; HNFJ1; MCKD2; Tamm-Horsfall urinary glycoprotein; THGP; THP; UMOD; Urehd1; urehr4; Urmodulin (Tamm-Horsfall protein); uromodulin; Uromodulin, secreted form; uromucoid; uromucoid uromucoid
Gene Symbols Umod
Host Species Sheep
Immunogen Mouse myeloma cell line NS0-derived recombinant mouse Uromodulin Ser24-Ala618.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22242
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

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