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Invitrogen™ USP15 Polyclonal Antibody
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Catalog No. PIPA593221
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PIPA593221 100 μL
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Catalog No. PIPA593221 Supplier Invitrogen™ Supplier No. PA593221
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SNHYGGMGGG HYTAFAKNKD DGKWYYFDDS SVSTASEDQI VSKAAYVLFY QRQDTFSGTG FFPLDRETKG ASAATGIPLE SDEDSNDNDN DIENENCMHT N; Positive Samples: 293T, LO2; Cellular Location: Cytoplasm, Nucleus.

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen USP15
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.53 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene USP15
Gene Accession No. Q8R5H1, Q9Y4E8
Gene Alias 4921514G19Rik; AI327321; deubiquitinating enzyme 15; deubiquitinating enzyme Ubp109; E430033I05Rik; Gcap18; granule cell antiserum positive 18; Kiaa0529; MGC131982; MGC149838; MGC74854; Ubiquitin carboxyl-terminal hydrolase 15; ubiquitin carboxyl-terminal hydrolase of 109 kDa; ubiquitin specific peptidase 15; ubiquitin specific protease 15; ubiquitin thioesterase 15; ubiquitin thiolesterase 15; ubiquitin-specific-processing protease 15; ubp109; UNPH-2; Unph4; Usp15
Gene Symbols USP15
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 852-952 of human USP15 (NP_0063041).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14479, 9958
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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