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USP19/ZMYND9 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A301586A

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Catalog No. 50-156-0763


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt.

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs), 1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
Specifications

Specifications

USP19/ZMYND9
Polyclonal
Unconjugated
USP19
deubiquitinating enzyme 19, KIAA0891, ubiquitin specific protease 19, ubiquitin thioesterase 19, ubiquitin thiolesterase 19, ubiquitin-specific-processing protease 19, zinc finger MYND domain-containing protein 9, ZMYND9
Rabbit
Antigen affinity chromatography
RUO
10869
4° C
Liquid
Immunoprecipitation
1 mg/ml
phosphate, tris citrate with 0.09% sodium azide; pH 7-8
O94966
USP19
Between 1 and 50
100 μL
Primary
Human
Antibody
IgG
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