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Invitrogen™ USP37 Polyclonal Antibody
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Catalog No. PIPA5100697
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PIPA5100697 100 μL
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Catalog No. PIPA5100697 Supplier Invitrogen™ Supplier No. PA5100697
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total USP37.

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen USP37
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Usp37
Gene Accession No. Q86T82
Gene Alias 4932415L06Rik; C330008N13Rik; Deubiquitinating enzyme 37; Kiaa1594; tmp_locus_50; ubiquitin carboxyl-terminal hydrolase 37; ubiquitin specific peptidase 37; ubiquitin specific peptidase 37-like; ubiquitin specific protease 37; ubiquitin thioesterase 37; ubiquitin thiolesterase 37; ubiquitin-specific-processing protease 37; USP37
Gene Symbols Usp37
Host Species Rabbit
Immunogen A synthesized peptide derived from human USP37(Accession Q86T82), corresponding to amino acid residues P760-E810.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100361658, 57695
Target Species Human, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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