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USP5 Mouse anti-Human, Clone: 3F12C10, Proteintech
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Catalog No. 501736646 Shop All Proteintech Group Inc Products
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50-173-6646 150 μL
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Catalog No. 50-173-6646 Supplier Proteintech Group Inc Supplier No. 662131IG150UL
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Description

Mouse Monoclonal Antibody

USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in uchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the uchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

Specifications

Antigen USP5
Applications Western Blot
Classification Monoclonal
Clone 3F12C10
Concentration 0.91 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene USP5
Gene Accession No. P45974
Gene Alias Deubiquitinating enzyme 5, Isopeptidase T, ISOT, Ubiquitin thiolesterase 5, USP5
Gene Symbols USP5
Host Species Mouse
Immunogen USP5 Fusion Protein Ag7575
Purification Method Protein A
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8078
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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