USP5 Mouse anti-Human, Clone: OTI2F5, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF501288

Catalog No. 50-166-0313

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in uchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the uchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

Specifications

• Antigen: USP5
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: USP5
• Gene Alias: ISOT
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8078
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2F5
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P45974
• Gene Symbols: USP5
• Immunogen: Full length human recombit protein of human USP5 produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1