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USP5 Mouse anti-Human, Clone: OTI2F5, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF501288

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in uchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the uchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.Specifications
USP5 | |
Monoclonal | |
Unconjugated | |
USP5 | |
ISOT | |
Mouse | |
Affinity Chromatography | |
RUO | |
8078 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
OTI2F5 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
P45974 | |
USP5 | |
Full length human recombit protein of human USP5 produced in HEK293T cell. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
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