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Invitrogen™ Varicella zoster Virus ORF47 Polyclonal Antibody
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Catalog No. PIPA567989
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100 μL
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PIPA567989 100 μL
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Catalog No. PIPA567989 Supplier Invitrogen™ Supplier No. PA567989
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Description

Rabbit Polyclonal Antibody

Varicella zoster Virus ORF47 Polyclonal Antibody for Western Blot

The ORF47 gene codes a multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and regulation of viral and cellular gene expression. It regulates the nuclear localization of viral envelopment factor proteins 24 and 27, by phosphorylating the protein kinase ORF66, indicating a role in nuclear egress. Disrupts host nuclear lamins, including LMNA and LMNB1. The ORF47 transcript phosphorylates the viral Fc receptor composed of glycoproteins E (gE) and I (gI). Phosphorylation of glycoprotein E (gE) by UL13 alters its subcellular localization, from the host early endosome to the plasma membrane. Participates in the transcriptional regulation of cellular and viral mRNAs mainly by phosphorylating the viral transcriptional regulator IE63.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Varicella zoster Virus ORF47
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Alias varicella zoster virus ge
Host Species Rabbit
Immunogen Synthesized peptide derived from human KR2_VZVD.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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