Invitrogen™ Varicella zoster Virus (strain Dumas) Polyclonal Antibody

Catalog No.	Quantity
PIPA5115477	100 μL

Catalog No. PIPA5115477 Supplier Invitrogen™ Supplier No. PA5115477

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total KITH_VZV7.

Varicella Zoster Virus (VZV), a member of the human herpes virus family, causes two distinct clinical manifestations: childhood chickenpox(Varicella) and shingles (zoster). Varicella is the outcome of the primary infection with VZV, whereas, zoster is the result of VZV reactivation from latently infected sensory ganglia which occurs precominantly in aging and immunosuppressed individuals. Glycoprotein E (gE), a 623 amino acid type I integral membrane protein, is expressed on plasma membranes and in the cytoplasm of VZV infected cells, where it is presumed to be present in the membranes of intracellular vesicles or organelles. VZV gE complexes with gI in the rough endoplasmic reticulum, and most gE exists in the form of gE to gI heterodimers in infected cells. VZV gE is also a predominant component of the virion envelope. The functions of gE, which is encoded by ORF68, are of particular interest because it has been demonstrated that ORF68 is essential for VZV replication. In contrast, the genes for gE proteins can be deleted from herpes simplex virus and pseudorabies virus, albeit with significant reductions in infectivity in cell culture and in animal models. Since the VZV genome does not encode a homologue of gD, VZV gE may have functions that are usually segregated between gD and gE, or the gE to gI complex, in other alphaherpesviruses.

Specifications

• Antigen: Varicella zoster Virus (strain Dumas)
• Applications: Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Alias: varicella zoster virus ge; Varicellovirus; VZV
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human virus KITH_VZV7, corresponding to a region within the internal amino acids.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Virus
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

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