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Invitrogen™ VAV1 Monoclonal Antibody (GT557)
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Catalog No. PIMA531488
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100 μL
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Catalog No. Quantity
PIMA531488 100 μL
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Catalog No. PIMA531488 Supplier Invitrogen™ Supplier No. MA531488
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Description

Mouse Monoclonal Antibody

Keep as concentrated solution. Predicted reactivity: Mouse (92%), Rat (92%), Pig (96%), Bovine (96%). Positive Control: Jurkat, NCI-H929. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The VAV1 gene, located on chromosome 19p13.2, encodes for a protein that functions as a guanine nucleotide exchange factor (GEF). Structurally, the VAV1 protein contains several functional domains, including Dbl homology (DH) and pleckstrin homology (PH) domains, which facilitate its role in exchange activity, and SH3 and SH2 domains, critical for signal transduction. VAV1 is primarily expressed in hematopoietic cells and plays a crucial role in the regulation of immune responses, particularly in T-cell receptor signaling. It influences actin cytoskeleton reorganization, cell proliferation, and differentiation, making it vital for proper immune system function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen VAV1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone GT557
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene VAV1
Gene Accession No. P15498, P27870
Gene Alias oncogene vav; p95; p95vav; Proto-oncogene vav; VAV; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav guanine nucleotide exchange factor 1; vav oncogene; vav proto-oncogene; VAV1; vav-T
Gene Symbols VAV1
Host Species Mouse
Immunogen Recombinant protein encompassing a sequence within the center region of human VAV1. The exact sequence is proprietary.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22324, 7409
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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