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Invitrogen™ VAV1 Polyclonal Antibody
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Catalog No. PIPA517834
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100 μL
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PIPA517834 100 μL
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Catalog No. PIPA517834 Supplier Invitrogen™ Supplier No. PA517834
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Description

Rabbit Polyclonal Antibody

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with Vav2, Vav3 or CelVav.

The VAV1 gene, located on chromosome 19p13.2, encodes for a protein that functions as a guanine nucleotide exchange factor (GEF). Structurally, the VAV1 protein contains several functional domains, including Dbl homology (DH) and pleckstrin homology (PH) domains, which facilitate its role in exchange activity, and SH3 and SH2 domains, critical for signal transduction. VAV1 is primarily expressed in hematopoietic cells and plays a crucial role in the regulation of immune responses, particularly in T-cell receptor signaling. It influences actin cytoskeleton reorganization, cell proliferation, and differentiation, making it vital for proper immune system function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen VAV1
Applications Flow Cytometry, Western Blot
Classification Polyclonal
Concentration 22 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene VAV1
Gene Accession No. P15498, P27870, P54100
Gene Alias oncogene vav; p95; p95vav; Proto-oncogene vav; VAV; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav guanine nucleotide exchange factor 1; vav oncogene; vav proto-oncogene; VAV1; vav-T
Gene Symbols VAV1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues surrounding Tyr174 of human Vav.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22324, 25156, 7409
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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