VCAM-1 Mouse anti-Human, Clone: 1B12F12, Proteintech

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-6726	Proteintech Group Inc 662941IG150UL	150 μL

Description

VCAM-1 (vascular cell adhesion protein 1, CD106, INCAM-110) is a cell surface sialoglycoprotein expressed by cytokine activated endothelium. VCAM-1 has a number of functions including the regulation of leukocyte migration, leukocyte-endothelial cell adhesion and signal transduction and may play a role in a number of inflammatory diseases. VCAM-1 is distributed across non-leukocyte and leukocyte cells. VCAM-1 expression is reportedly correlated with adhesion of melanoma, Burkitt lymphoma, osteosarcoma, and kidney carcinoma but not colon carcinoma cells to endothelial cells which may determine the site of tumor metastasis. VCAM-1 is a member of the Ig superfamily of adhesion molecules, is expressed at high levels on cytokine stimulated vascular endothelial cells, and at minimal levels on unstimulated endothelial cells. VCAM-1 is also present on follicular and inter-follicular dendritic cells of lymph nodes, myoblasts, and some macrophages. VCAM-1 serves as a ligand for leukocyte integrin alpha-beta (VLA-4 or CD49d/CD29) and mediates cell adhesion of leukocytes to activated endothelium. VCAM-1 plays a role in tumor metastasis, and may also be involved in the development of atherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms of VCAM-1 have been described.

Specifications

• Antigen: VCAM-1
• Concentration: 1.5 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: CD106, INCAM 100, L1CAM, V CAM 1, VCAM 1, VCAM1, VCAM-1
• Gene Symbols: VCAM1
• Isotype: IgG2a
• Purification Method: Protein A
• Product Type: Antibody

• Clone: 1B12F12
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human
• Gene Accession No.: P19320
• Gene ID (Entrez): 7412
• Immunogen: VCAM-1 Fusion Protein Ag24697
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: VCAM1