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VCAM-1 Mouse anti-Human, Clone: 1B12F12, Proteintech
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Catalog No. p-7212846 Shop All Proteintech Group Inc Products
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50-173-6726 150 μL
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Catalog No. 50-173-6726 Supplier Proteintech Group Inc Supplier No. 662941IG150UL
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Description

Mouse Monoclonal Antibody

VCAM-1 (vascular cell adhesion protein 1, CD106, INCAM-110) is a cell surface sialoglycoprotein expressed by cytokine activated endothelium. VCAM-1 has a number of functions including the regulation of leukocyte migration, leukocyte-endothelial cell adhesion and signal transduction and may play a role in a number of inflammatory diseases. VCAM-1 is distributed across non-leukocyte and leukocyte cells. VCAM-1 expression is reportedly correlated with adhesion of melanoma, Burkitt lymphoma, osteosarcoma, and kidney carcinoma but not colon carcinoma cells to endothelial cells which may determine the site of tumor metastasis. VCAM-1 is a member of the Ig superfamily of adhesion molecules, is expressed at high levels on cytokine stimulated vascular endothelial cells, and at minimal levels on unstimulated endothelial cells. VCAM-1 is also present on follicular and inter-follicular dendritic cells of lymph nodes, myoblasts, and some macrophages. VCAM-1 serves as a ligand for leukocyte integrin alpha-beta (VLA-4 or CD49d/CD29) and mediates cell adhesion of leukocytes to activated endothelium. VCAM-1 plays a role in tumor metastasis, and may also be involved in the development of atherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms of VCAM-1 have been described.

Specifications

Antigen VCAM-1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 1B12F12
Concentration 1.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene VCAM1
Gene Accession No. P19320
Gene Alias CD106, INCAM 100, L1CAM, V CAM 1, VCAM 1, VCAM1, VCAM-1
Gene Symbols VCAM1
Host Species Mouse
Immunogen VCAM-1 Fusion Protein Ag24697
Purification Method Protein A
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7412
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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