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Invitrogen™ VDAC Monoclonal Antibody (N152B/23), FITC
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Catalog No. PIMA545667
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100 μg
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Catalog No. Quantity
PIMA545667 100 μg
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Catalog No. PIMA545667 Supplier Invitrogen™ Supplier No. MA545667
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Description

Mouse Monoclonal Antibody

Mouse: 98% identity (279/283 amino acids identical). Rat: 98% identity (279/283 amino acids identical) >60% identity with VDAC2 and VDAC3. 1 μg/mL of MA5-45667 was sufficient for detection of VDAC1 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 30kDa. Does not cross-react with VDAC2 or VDAC3 (based on KO validation results). This antibody was formerly sold as clone S152B-23.

Voltage-dependent anion channel (VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. It was discovered in the mitochondrial outer membrane. It also is expressed in the plasma membrane. At least three different VDAC genes have been identified in vertebrates. VDAC proteins are known to play an essential role in cellular metabolism and in the early stages of apoptosis. For example, VDAC constitutes a major pathway by which metabolites such as ADP/ATP, succinate and citrate are exchanged between the cytosol and mitochondria. And VDAC1 in the plasma membrane establishes a novel level of apoptosis regulation putatively via its redox activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen VDAC
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone N152B/23
Concentration 1 mg/mL
Conjugate FITC
Formulation PBS, 9.09mM sodium bicarbonate with 640.91mM DMSO, 136.36mM ethanolamine and no preservative; pH 7.4
Gene VDAC1
Gene Accession No. P21796, Q60932, Q9Z2L0
Gene Alias AL033343; BR1-VDAC; Brain-derived voltage-dependent anion channel 1; hVDAC1; MGC111064; Mitochondrial outer membrane protein porin 1; Mitochondrial Porin; mVDAC1; mVDAC5; N2441; OMP2; Outer mitochondrial membrane protein porin 1; plasmalemmal porin; POR1; PORIN; Porin 31HL; porin 31HM; porin POR1; PORIN-31-HL; rVDAC1; VD; VDAC; VDAC1; VDAC-1; Vdac5; VDAC-5; voltage dependent anion channel 1; voltage-dependent anion channel 1; voltage-dependent anion-selective channel protein 1; Voltage-dependent anion-selective channel protein 5; YNL055C; YNL2441C
Gene Symbols VDAC1
Host Species Mouse
Immunogen Fusion protein amino acids 1-283 (full-length) of human VDAC1.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22333, 7416, 83529
Target Species Human, Mouse, Rat
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG2a
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