Invitrogen™ VDR Monoclonal Antibody (9A7gamma.E10.E4)

Catalog No.	Quantity
MA514617	500 μL

Catalog No. MA514617 Supplier Invitrogen™ Supplier No. MA514617

Description

Rat Monoclonal Antibody

MA5-14617 targets Vitamin D Receptor in GS and WB applications and shows reactivity with Amphibian, Chicken, Fish, Hamster, Human, mouse, Porcine, and Rat samples. The MA5-14617 immunogen is vitamin D receptor protein from chicken intestine.

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors. Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. Studies have found VDR in the intestine, bone, kidney, epidermis, and cells of the endocrine immune system. Repression of T-cell proliferation and interleukin-2 (IL-2) gene expression, for example, occurs when VDR binds within the IL-2 enhancer. Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)2D3 has been shown to interfere with assembly of nuclear factor of activated T-cells (NFATp)/Fos/Jun/DNA complex and subsequent IL-2 gene transcription. The corresponding gene for the vitamin D receptor is NR1I1.

Specifications

• Antigen: VDR
• Applications: Gel Shift, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 9A7gamma.E10.E4
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
• Gene: VDR
• Gene Accession No.: A3RGC1, O42392, P11473, P13053, P48281
• Gene Alias: 1,25-dihydroxyvitamin D3 receptor; HGNC:12679; I79_025795; Nr1i1; Nuclear receptor subfamily 1 group I member 1; PPP1R163; protein phosphatase 1, regulatory subunit 163; vdr; vdr.S; vdr-A; vitamin D (1,25- dihydroxyvitamin D3) receptor; vitamin D (1,25- dihydroxyvitamin D3) receptor S homeolog; vitamin D (1,25-dihydroxyvitamin D3) receptor; vitamin D nuclear receptor variant 1; vitamin D receptor; vitamin D receptor protein; vitamin D receptor S homeolog; Vitamin D3 receptor; XELAEV_18015993mg; xVDR
• Gene Symbols: VDR
• Host Species: Rat
• Immunogen: Vitamin D receptor protein from chicken intestine.
• Purification Method: Protein G
• Quantity: 500 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100767048, 22337, 24873, 395988, 396628, 7421
• Target Species: Amphibian, Chicken, Fish, Hamster, Human, Mouse, Pig, Rat
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b