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Tocris Bioscience™ Verdinexor
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Catalog No. 756950
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75-695-0 50 mg
75-691-0 10 mg
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Catalog No. 75-695-0 Supplier Tocris Bioscience™ Supplier No. 7569/50
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Description

Selective exportin-1 (XPO1/CRM1) inhibitor

Verdinexor is a selective exportin-1 (XPO1/CRM1) inhibitor. It potently inhibits influenza virus ribonucleoprotein (vRNP) export by disrupting XPO1-NEP binding and the replication of influenza virus A and B strains in vitro, including H1N1, H5N1 and H7N9 (IC50 values in the range 40 - 420 nM range). Verdinexor limits influenza A virus spread in mouse lung in vivo. In neuroblastoma, verdinexor suppresses cell proliferation and induces cell apoptosis. It also induces P53 nuclear accumulation and induces G0/G1 phase cell cycle arrest by activating P53 function. Verdinexor inhibits tumor growth in in vivo mouse models. Orally bioavailable.

Specifications

Chemical Name or Material (2 Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1 H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyridinyl)hydrazide
CAS 1392136-43-4
Quantity 50 mg
Target Antiviral Compounds
Molecular Formula C18H12F6N6O
Purity 0.98
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