Invitrogen™ Versican V0, V1 Neo Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA11748A

Catalog No. PA11748A

Description

PA1-1748A detects versican from human samples. PA1-1748A has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~70 kDa protein representing versican from mouse cumulus oocyte complexes. PA1-1748A immunogen is a synthetic peptide corresponding to residues C G G D(436) P E A A E(441) of human Versican V0/V1 Neo. This sequence is completely conserved between mouse and rat. This immunizing peptide (PEP-235) can be used for neutralization and control experiments. This polyclonal antibody has been referred to as: JSCDPE or DPEAAE.

Versican is a member of the family of large aggregating proteoglycans (also including aggrecan, brevican, and neurocan). The protein shows wide tissue distribution which includes fibrous, articular, and elastic cartilages, as well as nervous, epidermal, arterial, and loose connective tissues. Versican V1 has been shown to enhance cell proliferation, and also induce cell transformation and protect cells from apoptosis. This was demonstrated through its ability to downregulate the expression of proapoptotic Bad. Versican's existence as a extracellular matrix protein in human airways has also lead to the discovery of an inflammatory role in asthmatics.

Specifications

• Antigen: Versican V0, V1 Neo
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: VCAN
• Gene Alias: Chondroitin sulfate proteoglycan 2; Chondroitin sulfate proteoglycan core protein 2; CSPG2; ERVR; GHAP; Glial hyaluronate-binding protein; large fibroblast proteoglycan; PGM; PG-M; V1 Neo; VCAN; versican; versican core protein; versican proteoglycan; Versican V0; WGN; WGN 1; WGN1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1462
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 2 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: P13611
• Gene Symbols: VCAN
• Immunogen: Synthetic peptide corresponding to residues C G G D(436) P E A A E(441) of human Versican V0/V1 Neo.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov