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Invitrogen™ Vinculin Polyclonal Antibody
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Catalog No. PIPA529688
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100 μL
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PIPA529688 100 μL
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Catalog No. PIPA529688 Supplier Invitrogen™ Supplier No. PA529688
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: NT2D1, Mouse brain, HeLa. Predicted reactivity: Human (99%), Mouse (98%), Rat (98%), Pig (98%), Chicken (93%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Vinculin
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.33 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene VCL
Gene Accession No. P18206, P85972, Q64727
Gene Alias 9430097D22; AA571387; AI462105; AW545629; CMD1W; CMH15; epididymis luminal protein 114; HEL114; metavinculin; meta-vinculin; metavinculin {ECO:0000250; MV; MVCL; RP11-178G16.3; UniProtKB:P18206}; unnamed protein product; Vcl; vcl {ECO:0000250; VIN; vinc; vinc 1; VINC1; Vinculin; vinculin {ECO:0000250
Gene Symbols VCL
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Vinculin. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22330, 305679, 7414
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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