Apexbio Technology LLC Vortioxetine 508233-74-7 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A39265.1

Vortioxetine (CAS 508233-74-7) is a multimodal antidepressant currently under investigation for the treatment of depression It demonstrates high affinity for recombinant human serotonin receptors including 5-HT1A (Ki 15 nM) 5-HT1B (Ki 33 nM) 5-HT3A (Ki 3 7 nM) 5-HT7 (Ki 19 nM) noradrenergic 1 receptors (Ki 46 nM) and the serotonin transporter SERT (Ki 1 6 nM) Vortioxetine acts as an antagonist at 5-HT3A and 5-HT7 partial agonist at 5-HT1B agonist at 5-HT1A and exhibits potent SERT inhibition In vivo studies show that short-term administration increases extracellular 5-HT in rat brain Vortioxetine s multimodal activity makes it a valuable tool for research into serotonergic modulation and antidepressant mechanisms

Catalog No. 50-000-96265