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VPS4B Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. 501731714 Shop All Proteintech Group Inc Products
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50-173-1714 150 μL
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Catalog No. 50-173-1714 Supplier Proteintech Group Inc Supplier No. 176731AP150UL
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Description

Rabbit Polyclonal Antibody

Class E vacuolar protein sorting (vps) proteins are necessary for appropriate sorting of receptors in the yeast endocytic pathway. The yeast Vps4p is a member of the AAA protein family (ATPases associated with diverse cellular activities) and plays an important role in transporting proteins out of a prevacuolar endosomal compartment. In human, two non-allelic orthologous proteins (VPS4A and VPS4B) of yeast Vps4p are known and can form heteromeric complexes with each other. Both VPS4 (also known as SKD1 in mouse) proteins are class E VPSs and are involved in intracellular protein trafficking, similar to Vps4p in yeast. A human CHMP1 protein, which is implicated in multivesicular body formation, physically interacts with VPS4. HIV-1 uses cellular machinery to bud from infected cells and requires VPS4 and TSG101/VPS23 for this budding process. Domit negative mutant of VPS4 inhibit vacuolar protein sorting and also arrest HIV-1 and MLV budding. Thus, retroviruses normally use the VPS pathway to form multivesicular bodies during the budding process.

Specifications

Antigen VPS4B
Applications Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.23 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene VPS4B
Gene Accession No. O75351, P46467
Gene Alias MIG1, Protein SKD1, SKD1, VPS4 2, VPS42, VPS4B
Gene Symbols Vps4b
Host Species Rabbit
Immunogen VPS4B Fusion Protein Ag11610
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20479, 360834, 9525
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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