VTCN1 Mouse anti-Human, Clone: OTI9E9, liquid, TrueMAB™

Catalog No.	Quantity
50-168-3181	100 μL

Catalog No. 50-168-3181 Supplier OriGene Supplier No. TA810072

Description

Mouse Monoclonal Antibody

B7-H4 (B7x, VTCN1) a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response. B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 is expressed primarily on the membrane of lymphoid cells, and as an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, it is involved in mediating cellular and humoral immune responses. Overexpression of B7-H4 is associated with certain maligcies, including ovarian and breast cancer, which may be a mechanism by which tumor cells suppress T cell immunity and facilitate tumor progression. Further, VTCN1 may be a useful biomarker for the early detection of ovarian cancer and Renal Cell Carcinoma (RCC).

Specifications

• Antigen: VTCN1
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI9E9
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: VTCN1
• Gene Accession No.: Q7Z7D3
• Gene Alias: B7-H4, B7H4, B7S1, B7X, B7h.5, PRO1291, VCTN1
• Gene Symbols: VTCN1
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 31-117 of human VTCN1 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 79679
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a