Invitrogen™ WAC Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5143930

Catalog No. PIPA5143930

Description

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human A431 whole cell, human THP-1 whole cell, human Raji whole cell, human K562 whole cell, human U20S whole cell, human SK-OV-3 whole cell, rat brain tissue, rat PC-12 whole cell, mouse thymus tissue, mouse SP2/0 whole cell. ICC/IF: A431 cell. Flow: HepG2 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.

Specifications

• Antigen: WAC
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Wac
• Gene Alias: 1110067P07Rik; A230035H12Rik; AI256735; AI256776; BM-016; DESSH; Kiaa1844; PRO1741; RGD1562407; Wac; WW domain containing adaptor with coiled-coil; WW domain-containing adapter protein with coiled-coil; WW domain-containing adaptor with coiled-coil; WW domain-containing protein 4; Wwp4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 225131, 307029, 51322
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: ELISA, Flow Cytometry, Western Blot, Immunocytochemistry
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and 0.01mg sodium azide
• Gene Accession No.: Q924H7, Q9BTA9
• Gene Symbols: Wac
• Immunogen: E.coli-derived human WAC recombinant protein (Position: Q459-V647).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG