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WDR48 Rabbit anti-Human, Mouse, Rat, Polyclonal, liquid, OriGene
SDP

Rabbit Polyclonal Antibody

Supplier:  OriGene TA890061

Encompass_Preferred

Catalog No. 50-168-4774


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Description

Description

Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintece of the viral genome via its interaction with HPV11 helicase E1.
Specifications

Specifications

WDR48
Polyclonal
PBS with 50% glycerol and 0.02% sodium azide
Q8BH57, Q8TAF3
Wdr48
Recombit protein of human WDR48
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
Western Blot
Unconjugated
WDR48
P80, SPG60, UAF1
Rabbit
Antigen Affinity Chromatography
RUO
363164, 57599, 67561
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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