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WDR48 Rabbit anti-Human, Mouse, Rat, Polyclonal, liquid, OriGene
SDP

Catalog No. 501684774
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50-168-4774 100 μL
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Catalog No. 50-168-4774 Supplier OriGene Supplier No. TA890061
May include imposed supplier surcharges.
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Description

Rabbit Polyclonal Antibody

Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintece of the viral genome via its interaction with HPV11 helicase E1.

Specifications

Antigen WDR48
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene WDR48
Gene Accession No. Q8BH57, Q8TAF3
Gene Alias P80, SPG60, UAF1
Gene Symbols Wdr48
Host Species Rabbit
Immunogen Recombit protein of human WDR48
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 363164, 57599, 67561
Target Species Human, Mouse, Rat
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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