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Invitrogen™ WEE2 Polyclonal Antibody
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Catalog No. PIPA5106772
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100 μL
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PIPA5106772 100 μL
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Catalog No. PIPA5106772 Supplier Invitrogen™ Supplier No. PA5106772
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total WEE2.

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II (PubMed:29606300). Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen WEE2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene WEE2
Gene Accession No. P0C1S8, Q66JT0
Gene Alias Gm1065; mWee1B; WEE1 homolog 2 (S. pombe); WEE1B; Wee1B kinase; wee1-like protein kinase 1B; Wee1-like protein kinase 2; Wee2
Gene Symbols WEE2
Host Species Rabbit
Immunogen A synthesized peptide derived from human WEE2(Accession P0C1S8), corresponding to amino acid residues V153-N203.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 381759, 494551, 502750
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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