Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. WHI-P 154

WHI-P 154

Catalog No. 31155
Change view
Click to view available options
Quantity:
5 mg
25 mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
31-155 5 mg
31-152-5 25 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Catalog No. 31-155 Supplier R&D Systems Supplier No. 3115/5
This item is not returnable. View return policy

Description

JAK3 kinase inhibitor. Also inhibits EGFR

WHI-P 154 is a JAK3 inhibitor (IC50 = 1.8 μM) that displays no activity at JAK1 or JAK2. Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro. Also inhibits other common kinases including EGFR (IC50 = 4 nM), Src, Abl, VEGFR, MAPK and PI 3-K and induces apoptosis in human glioblastoma cell lines (IC50 = 158 μM). Induces differentiation of neural progenitor cells.

Specifications

Chemical Name or Material 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol
CAS 211555-04-3
Assay Percent Range >99%
Quantity 5 mg
Molecular Formula C16H14BrN3O3
Formula Weight Observed MW: 376.2
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.