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Invitrogen™ WIBG Polyclonal Antibody
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Catalog No. PIPA565245
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100 μL
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PIPA565245 100 μL
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Catalog No. PIPA565245 Supplier Invitrogen™ Supplier No. PA565245
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KEKRRQQQEKG EAEALSRTLD KVSLEETAQL PSAPQGSRAA PTAASDQPDS AATTEKAKKI KNLK Highest antigen sequence identity to the following orthologs - mouse 82%, rat 78%.

Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen WIBG
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PYM1
Gene Accession No. Q9BRP8
Gene Alias A030010B05Rik; Partner of Y14 and mago; protein wibg homolog; PYM; PYM homolog 1 exon junction complex-associated factor; PYM homolog 1, exon junction complex associated factor; Pym1; RGD1306096; WIBG; within bgcn homolog; within bgcn homolog (Drosophila)
Gene Symbols PYM1
Host Species Rabbit
Immunogen Recombinant Human WIBG. Recombinant protein control fragment (Product #RP-97825).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84305
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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