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Apexbio Technology LLC Wiskostatin 253449-04-6 1mg

Supplier: Apexbio Technology LLC B76661

Wiskostatin (CAS 253449-04-6) is a small-molecule inhibitor targeting neural Wiskott-Aldrich syndrome protein (N-WASP) It is designed to inhibit N-WASP-mediated actin polymerization thereby modulating actin cytoskeletal dynamics Wiskostatin exerts its biological activity primarily through binding the regulatory GTPase-binding domain (GBD) of N-WASP stabilizing its inactive conformation This inhibits activation mediated by Cdc42 and phosphatidylinositol 4 5-bisphosphate (PIP2) reducing Arp2/3-complex-dependent actin nucleation and polymerization Based on these pharmacological properties Wiskostatin holds research potential in investigating actin dynamics particularly in neuronal processes such as dendritic spine morphogenesis and synapse formation
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