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Invitrogen™ WNT7A Polyclonal Antibody
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Catalog No. PIPA596320
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PIPA596320 100 μL
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Catalog No. PIPA596320 Supplier Invitrogen™ Supplier No. PA596320
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Description

Rabbit Polyclonal Antibody

Positive Samples: Mouse kidney; Cellular Location: extracellular matrix, extracellular space Immunogen sequence: KEKQGQYHRD EGWKWG.

Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. It is expressed in placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family, ultimately leading to the disruption of β-catenin degradation. Intracellular accumulation of β-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to induce the expression of numerous genes. Increased Wnt/β-catenin signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers.
TRUSTED_SUSTAINABILITY

Specifications

Antigen WNT7A
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.28 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene Wnt7a
Gene Accession No. O00755, P24383
Gene Alias AI849442; postaxial hemimelia; protein Wnt-7a; proto-oncogene Wnt7a protein; px; tw; wingless-related MMTV integration site 7A; wingless-type MMTV integration site 7A; wingless-type MMTV integration site family member 7A; wingless-type MMTV integration site family, member 7A; Wnt family member 7A; WNT7A; Wnt-7a
Gene Symbols Wnt7a
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 101-200 of human WNT7A (NP_0046162).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22421, 7476
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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