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Enzo Life Sciences Wortmannin (5 mg). CAS: 19545-26-7
Supplier: Enzo Life Sciences BMLST4150005
Potent and selective inhibitor of phosphatidyl-inositol 3-kinase. Active in purified preparations and cytosolic fractions(IC50 = 5nM) and is highly cell permeable. Inhibits fMLP induced PIP3 and superoxide anion production (IC50 = 50nM) in guinea pig neutrophils and blocks the metabolic effects of insulin in isolated rat adipocytes without affecting the insulin receptor tyrosine kinase activity. Covalently binds to PI 3-kinase and is selective, inhibiting other kinases such as PI 4-kinase and myosin light chain kinase at concentrations 100-fold higher than that required for inhibition of PI 3-kinase. The half-life of wortmannin in culture media is quite short (8-13 minutes), care should be taken to account for this decomposition when planning experiments. Alternative name: KY 12420. Purity: ≥98% (HPLC, TLC). Solubility: Soluble in DMSO (50mg/ml), methanol (5mg/ml) or 100% ethanol (25mg/ml). Long Term Storage: -20°C.
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