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Invitrogen™ WRN Polyclonal Antibody
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Catalog No. PIPA527319
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100 μL
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PIPA527319 100 μL
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Catalog No. PIPA527319 Supplier Invitrogen™ Supplier No. PA527319
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
TRUSTED_SUSTAINABILITY

Specifications

Antigen WRN
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene WRN
Gene Accession No. Q14191
Gene Alias AI846146; DKFZp686C2056; DNA helicase, RecQ-like type 3; exonuclease WRN; RecQ protein-like 2; RecQ3; RECQL2; RECQL3; RGD1564788; similar to Werner syndrome helicase homolog; Werner syndrome ATP-dependent helicase; Werner syndrome ATP-dependent helicase homolog; Werner syndrome homolog (human); Werner syndrome RecQ like helicase; Werner syndrome, RecQ helicase-like; WRN
Gene Symbols WRN
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human WRN. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7486
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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