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Invitrogen™ WWC1 Recombinant Rabbit Monoclonal Antibody (1H4L22)

Catalog No. 703009
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Catalog No. Quantity
70-300-9 100 μg
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Catalog No. 70-300-9 Supplier Invitrogen™ Supplier No. 703009
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with Monkey, Dog, Pig. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

WWC1 (Protein KIBRA) is a probable regulator of the Hippo/SWH signaling pathway. This pathway plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. WWC1, along with NF2, can synergistically induce the phosphorylation of LATS1 and LATS2. It acts as a transcriptional coactivator of ESR1 - which plays an essential role in DYNLL1-mediated ESR1 transactivation. WWC1 also functions as a regulatior of collagen-stimulated activation of the ERK/MAPK cascade.
TRUSTED_SUSTAINABILITY

Specifications

Antigen WWC1
Applications Immunocytochemistry
Classification Recombinant Monoclonal
Clone 1H4L22
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2-7.4
Gene WWC1
Gene Accession No. Q8IX03
Gene Alias AA408228; AU017197; BC037006; FLJ10865; FLJ23369; HBeAg-binding protein 3; HBEBP3; HBEBP36; Kiaa0869; KIBRA; Kidney and brain protein; MEMRYQTL; mKIAA0869; PPP1R168; Protein KIBRA; protein phosphatase 1, regulatory subunit 168; protein WWC1; RGD1308329; WW and C2 domain containing 1; WW domain-containing protein 1; WW, C2 and coiled-coil domain containing 1; WWC1
Gene Symbols WWC1
Host Species Rabbit
Immunogen Protein corresponding to human WWC1 [aa772-aa851].
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23286
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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