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  5. Tocris Bioscience™ XIE62-1004

Tocris Bioscience™ XIE62-1004
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Catalog No. 787850
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Catalog No. Quantity
78-785-0 50 mg
78-781-0 10 mg
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Catalog No. 78-785-0 Supplier Tocris Bioscience™ Supplier No. 7878/50
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Description

Inducer of autophagy via interaction of p62 and LC3

XIE62-1004 is an inducer of p62-LC3 interaction. Binds to the ZZ domain of p62, leading to p62 self-aggregation and interaction with LC3 on autophagosome membranes; facilitates delivery of cargo proteins to the autophagosome for degradation. Active in vitro and in vivo in a concentration- and time-dependent manner and is specific for wild type p62. Induces degradation of mutant huntingtin in vitro. Can also be used in AUTAC protein degradation systems to induce autophagy through p62 self-aggregation and LC3 interaction.

Specifications

Chemical Name or Material 2-[[[3,4-Bis(phenylmethoxy)phenyl]methyl]amino]ethanol hydrochloride
CAS 2421146-32-7
Quantity 50 mg
Target p62/SQSTM1
Molecular Formula C23H25NO3.HCl
Purity 0.98
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