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XPA Monoclonal Antibody (12F5), Invitrogen™

Catalog No. PIMA513835
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500 μL
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Catalog No. Quantity
PIMA513835 500 μL
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Catalog No. PIMA513835 Supplier Thermo Scientific Supplier No. MA513835

Description

Mouse Monoclonal Antibody

MA5-13835 targets XPA in IHC (P) and WB applications and shows reactivity with Human samples. The MA5-13835 immunogen is recombinant human XPA protein.

The XPA (xeroderma pigmentosumgroup A) protein specifically recognizes the UV-orchemically damaged DNA lesions, and triggers thenucleotide excision repair process. XPA binds to thereplication protein A (RPA) or the excision repaircross complementing 1 protein (ERCC 1). In the absence of nucleotide excision repair persisting (unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and μgtimately to cancer. Xeroderma pigmentosum patients have a >2000 fold increased risk to develop skin cancer atsun-exposed areas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen XPA
Applications Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 12F5
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene XPA
Gene Accession No. P23025
Gene Alias AI573865; DNA repair protein complementing XP-A cells; DNA repair protein complementing XP-A cells homolog; excision repair-controlling; mutant xeroderma pigmentosum complementation group A; xeroderma pigmentosum group A-complementing protein; Xeroderma pigmentosum group A-complementing protein homolog; xeroderma pigmentosum, complementation group A; XP1; XPA; XPA, DNA damage recognition and repair factor; Xpac
Gene Symbols XPA
Host Species Mouse
Immunogen Recombinant human XPA protein
Purification Method Protein A
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7507
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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