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Invitrogen™ XPA Polyclonal Antibody
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Catalog No. PIPA5119824
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100 μL
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PIPA5119824 100 μL
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Catalog No. PIPA5119824 Supplier Invitrogen™ Supplier No. PA5119824
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Description

Rabbit Polyclonal Antibody

Positive Control: Hela cell lysate, A431 cell lysate, rat large intestine tissue, human thyroid tissue, human colon carcinoma tissue, human skin tissue, human prostate carcinoma tissue, human breast tissue, human breast carcinoma tissue, human stomach carcinoma tissue, human small intestine tissue, mouse testis tissue, mouse kidney tissue. Subcellular Location: Nucleus.

The XPA (xeroderma pigmentosumgroup A) protein specifically recognizes the UV-orchemically damaged DNA lesions, and triggers thenucleotide excision repair process. XPA binds to thereplication protein A (RPA) or the excision repaircross complementing 1 protein (ERCC 1). In the absence of nucleotide excision repair persisting (unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and ultimately to cancer. Xeroderma pigmentosum patients have a >2000 fold increased risk to develop skin cancer atsun-exposed areas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen XPA
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene XPA
Gene Accession No. P23025, Q64267
Gene Alias AI573865; DNA repair protein complementing XP-A cells; DNA repair protein complementing XP-A cells homolog; excision repair-controlling; mutant xeroderma pigmentosum complementation group A; xeroderma pigmentosum group A-complementing protein; Xeroderma pigmentosum group A-complementing protein homolog; xeroderma pigmentosum, complementation group A; XP1; XPA; XPA, DNA damage recognition and repair factor; Xpac
Gene Symbols XPA
Host Species Rabbit
Immunogen Synthetic peptide within human XPA aa 20-60.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22590, 298074, 7507
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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