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Invitrogen™ XPC Polyclonal Antibody
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Catalog No. APS956
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100 μL
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APS956 100 μL
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Catalog No. APS956 Supplier Invitrogen™ Supplier No. PA3956
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Description

Rabbit Polyclonal Antibody

PA3-956 detects XPC in human and mouse cells. PA3-956 has been successfully used in Western blotting and ICC/IF procedures. By Western blot it detects a ~125 kDa protein representing XPC. The PA3-956 immunogen is two synthetic peptides, individually conjugated to the C-Terminus and N-Terminus respectively of human XPC.

This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen XPC
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Whole Serum with 0.05% sodium azide
Gene XPC
Gene Accession No. P51612, Q01831
Gene Alias DNA repair protein complementing XP-C cells; DNA repair protein complementing XP-C cells homolog; mutant xeroderma pigmentosum group C; NER; p125; RAD4; Xeroderma pigmentosum group C-complementing protein; Xeroderma pigmentosum group C-complementing protein homolog; xeroderma pigmentosum, complementation group C; XP3; XPC; XPC complex subunit, DNA damage recognition and repair factor; XPCC
Gene Symbols XPC
Host Species Rabbit
Immunogen Two synthetic peptides, individually conjugated to the C-Terminus and N-Terminus respectively of human XPC.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22591, 7508
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov
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