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Invitrogen™ XPF Polyclonal Antibody
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Catalog No. PIPA5104474
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100 μL
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PIPA5104474 100 μL
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Catalog No. PIPA5104474 Supplier Invitrogen™ Supplier No. PA5104474
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total XPF.

The structure specific ERCC 1 / XPF endonuclease complex is implicated in the repair of two distinct types of lesions in DNA: NER for UV induced lesions and bulky chemical adducts; and recombination repair of the very genotoxic interstrand cross links. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells, XPG cleaves 3' of the DNA lesion while the ERCC1 / XPF complex makes the 5' incision. ERCC1 / XPF probably plays a role in processing partially processed recombination intermediates.
TRUSTED_SUSTAINABILITY

Specifications

Antigen XPF
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ERCC4
Gene Accession No. Q92889, Q9QZD4
Gene Alias AI606920; DNA excision repair protein ERCC-4; DNA repair endonuclease subunit; DNA repair endonuclease XPF; DNA repair protein complementing XP-F cells; ERCC excision repair 4, endonuclease catalytic subunit; ERCC11; ERCC4; Ercc4 protein-like; excision repair cross-complementation group 4; excision repair cross-complementing rodent repair deficiency, complementation group 4; excision-repair, complementing defective, in Chinese hamster; FANCQ; RAD1; RGD1560340; Xeroderma pigmentosum group F-complementing protein; xeroderma pigmentosum, complementation group F; XFEPS; XPF
Gene Symbols ERCC4
Host Species Rabbit
Immunogen A synthesized peptide derived from human ERCC4(Accession Q92889), corresponding to amino acid residues F813-C863.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2072, 304719, 50505
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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