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Tocris Bioscience™ xStAx-VHLL
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Catalog No. 7298100U
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100 μg
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7298100U 100 μg
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Catalog No. 7298100U Supplier Tocris Bioscience™ Supplier No. 7298/100U
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Description

Selective peptide-based β-catenin Degrader (PROTAC™)

xStAx-VHLL is a selective peptide-based β-catenin Degrader (PROTAC™). Comprises a β-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces β-catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively degrades β-catenin over other Wnt signaling pathway components. Inhibits tumor growth in APCmin/+ mice, with constitutively active Wnt signaling, and reduces survival of patient-derived colorectal cancer cell organoids. PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Purity 95%
Content And Storage Store at -20°C
Quantity 100 μg
Target Entry Active Degraders
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