YAP1 Rabbit anti-Human, Mouse, Zebrafish, Polyclonal, Proteintech

Catalog No.	Quantity
50-559-280	150 μL

Catalog No. 50-559-280 Supplier Proteintech Group Inc Supplier No. 135841AP150UL

Description

Rabbit Polyclonal Antibody

This antibody is a rabbit polyclonal antibody. The calculated molecular weight of YAP1 is 54 kDa, but phosphorylated YAP1 is about 65 kDa.

YAP1 (Yes-Associated Protein) is a founding member of the WW domain family of proteins, transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. YAP can act both as a coactivator and corepressor and is the critical downstream regulatory target in the Hippo signaling pathway. The Hippo signaling pathway plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Also plays key roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and cell migration. Mutations in the IRF5 gene results in coloboma.

Specifications

• Antigen: YAP1
• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
• Classification: Polyclonal
• Concentration: 0.3 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: YAP1
• Gene Accession No.: P46937, P46938, Q1L8J7
• Gene Alias: 65 kDa Yes associated protein, YAP, YAP1, YAP2, YAP65, YKI, Yorkie homolog
• Gene Symbols: yap1
• Host Species: Rabbit
• Immunogen: YAP1 Fusion Protein Ag4510
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10413, 22601, 561411
• Target Species: Human, Mouse, Zebrafish
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG