YAP1 Rabbit anti-Human, Mouse, Zebrafish, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 135841AP150UL

Catalog No. 50-559-280

Description

This antibody is a rabbit polyclonal antibody. The calculated molecular weight of YAP1 is 54 kDa, but phosphorylated YAP1 is about 65 kDa.

YAP1 (Yes-Associated Protein) is a founding member of the WW domain family of proteins, transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. YAP can act both as a coactivator and corepressor and is the critical downstream regulatory target in the Hippo signaling pathway. The Hippo signaling pathway plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Also plays key roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and cell migration. Mutations in the IRF5 gene results in coloboma.

Specifications

• Antigen: YAP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: YAP1
• Gene Alias: 65 kDa Yes associated protein, YAP, YAP1, YAP2, YAP65, YKI, Yorkie homolog
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10413, 22601, 561411
• Content And Storage: -20°C
• Form: Liquid

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
• Concentration: 0.3 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P46937, P46938, Q1L8J7
• Gene Symbols: yap1
• Immunogen: YAP1 Fusion Protein Ag4510
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Zebrafish
• Product Type: Antibody
• Isotype: IgG