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  5. Tocris Bioscience™ Z 944

Tocris Bioscience™ Z 944
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Catalog No. 636750
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Catalog No. Quantity
63-675-0 50 mg
63-671-0 10 mg
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Catalog No. 63-675-0 Supplier Tocris Bioscience™ Supplier No. 6367/50
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Description

CaV3.x blocker

Z 944 is a selective T-type Ca2+ channel blocker (IC50 values are 50 to 160 nM for hCav3.1, hCav3.2 and hCav3.3). Exhibits 50 to 600 fold selectivity for Cav3.x channels over related ion channels (Cav1.2, hERG and Nav1.5). Has no effect on action potential properties in isolated heart Purkinje fibers and no adverse effects on ECG parameters in vivo. Exhibits anti-seizure effects in animal models.

Specifications

Chemical Name or Material 4-[[(3-Chloro-5-fluorobenzoyl)amino)methyl]-N-(1,1-dimethylethyl)-1-piperidineacetamide
CAS 1199236-64-0
Quantity 50 mg
Molecular Formula C19H27ClFN3O2
Formula Weight 383.89
Purity 98%
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