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Tocris™ Z-Guggulsterone

Broad spectrum steroid receptor ligand. More active isomer of guggulsterone (Cat. No. 2013)

Manufacturer:  Tocris™ 3570/10

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Catalog No. 35-701-0R


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Disclaimers:

For Research Use Only


Specifications

Description

Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252nM respectively) and weak androgen receptor agonist (Ki = 315nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo. More active isomer of guggulsterone (Cat. No. 2013).
  • Chemical Name: (Z)-Pregna-4,17(20)-diene-3,16-dione
  • Formula: C21H28O2
  • CAS Number: 39025-23-5
  • Solubility: Soluble to 25mM in DMSO and to 10mM in ethanol with gentle warming
  • Purity: >98
Description & Specifications

Specifications

Z-Guggulsterone
>98
10mg
Z-Guggulsterone
312.45
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