Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252nM respectively) and weak androgen receptor agonist (Ki = 315nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo. More active isomer of guggulsterone (Cat. No. 2013).
Chemical Name: (Z)-Pregna-4,17(20)-diene-3,16-dione
CAS Number: 39025-23-5
Solubility: Soluble to 25mM in DMSO and to 10mM in ethanol with gentle warming
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