Thermo Scientific Chemicals Z-Val-Val-Nle Diazomethyl Ketone

Description

CAS: 155026-49-6 | C25H37N5O5, C₂₅H₃₇N₅O₅ | 487.60 g/mol

Z-Val-Val-Nle diazomethyl ketone is used as an irreversible cathepsin inhibitor that is 380 times more effective in inactivating cathepsin S than L. It is often abbreviated as DMK. Peptidyl diazomethyl ketones are specific inactivators of thiol proteinases.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Specifications

Chemical Identifiers

• CAS: 155026-49-6
• Molecular Formula: C₂₅H₃₇N₅O₅, C25H37N5O5
• Molecular Weight (g/mol): 487.60
• InChI Key: IIPZPLSBQVJCBO-UHFFFAOYNA-N
• Synonym: C-3890; Z-Val-Val-Nle-DMK
• IUPAC Name: benzyl N-[1-({1-[(1-diazo-2-oxoheptan-3-yl)carbamoyl]-2-methylpropyl}carbamoyl)-2-methylpropyl]carbamate
• SMILES: CCCCC(NC(=O)C(NC(=O)C(NC(=O)OCC1=CC=CC=C1)C(C)C)C(C)C)C(=O)C=[N+]=[N-]

• Quantity: 50 mg
• Description: White to Off-white
• Content And Storage: -30°C to -10°C
• For Use With (Application): Inactivates thiol proteinases; an irreversible cathepsin inhibitor
• Formula Weight: 487.60g/mol
• Product Type: Signal Transduction Reagent
• Form: Powder

Safety and Handling

Recommended Storage

Store at -20°C

SDS

RUO – Research Use Only