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Invitrogen™ ZBP1 Polyclonal Antibody
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Catalog No. PIPA520455
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100 μg
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PIPA520455 100 μg
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Catalog No. PIPA520455 Supplier Invitrogen™ Supplier No. PA520455
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Description

Rabbit Polyclonal Antibody

Suggested positive controls are mouse small intestine or human small intestine tissue lysate. PA5-20455 can be used with blocking peptide PEP-0572. PA5-20455 detects ZBP1 in WB application with human samples.

Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZBP1
Applications Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene ZBP1
Gene Accession No. Q8VDA5, Q9H171, Q9QY24
Gene Alias 2010010H03Rik; C20orf183; Dai; Dlm1; DLM-1; DNA-dependent activator of IFN-regulatory factors; DNA-dependent activator of IRFs; mZaDLM; RP4-718J7.1; Tumor stroma and activated macrophage protein DLM-1; Zbp1; Z-DNA binding protein 1; Z-DNA-binding protein 1
Gene Symbols ZBP1
Host Species Rabbit
Immunogen An 18 amino acid synthetic peptide from near the carboxy terminus of human ZBP1. The immunogen is located within the last 50 amino acids of ZBP1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 171091, 58203, 81030
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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