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Invitrogen™ ZBP1 Polyclonal Antibody
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Catalog No. PIPA5143928
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100 μg
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PIPA5143928 100 μg
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Catalog No. PIPA5143928 Supplier Invitrogen™ Supplier No. PA5143928
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Description

Rabbit Polyclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: rat liver tissue, mouse kidney tissue, mouse HEPA1-6 whole cell, rat thymus tissue, mouse thymus tissue. ICC/IF: RM-1 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZBP1
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and no preservative
Gene ZBP1
Gene Accession No. Q8VDA5, Q9QY24
Gene Alias 2010010H03Rik; C20orf183; Dai; Dlm1; DLM-1; DNA-dependent activator of IFN-regulatory factors; DNA-dependent activator of IRFs; mZaDLM; RP4-718J7.1; Tumor stroma and activated macrophage protein DLM-1; Zbp1; Z-DNA binding protein 1; Z-DNA-binding protein 1
Gene Symbols ZBP1
Host Species Rabbit
Immunogen E.coli-derived mouse DAI/Zbp1 recombinant protein (Position: A2-D382).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 171091, 58203
Target Species Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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