ZBTB4 Monoclonal Antibody (OTI1F6), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA811368

Catalog No. 50-168-3998

Description

The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determit of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions; this degradation increases with DNA damage.

Specifications

• Antigen: ZBTB4
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9P1Z0
• Gene Symbols: ZBTB4
• Immunogen: Human recombit protein fragment corresponding to amino acids 788-1013 of human ZBTB4 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1F6
• Conjugate: Unconjugated
• Gene: ZBTB4
• Gene Alias: KAISO-L1, ZNF903
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57659
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid