ZDHHC13, Mouse anti-Human, Clone: 26D1, Millipore Sigma™

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma MABT1498100UL

Catalog No. MABT1498100

Description

Anti-ZDHHC13, clone 26D1, Cat. No. MABT1498, is a mouse monoclonal antibody that detects Palmitoyltransferase ZDHHC13 and has been tested for use in Western Blotting.

Palmitoyltransferase ZDHHC13 (UniProt: Q8IUH4; also known as EC: 2.3.1.22, Huntingtin-interacting protein 14-related protein, HIP14-related protein, Huntingtin-interacting protein HIP3RP, Putative MAPK-activating protein PM03, Putative NF-kappa-B-activating protein 209, Zinc finger DHHC domain-containing protein 13, DHHC-13) is encoded by the ZDHHC13 (also known as HIP14L, HIP3RP) gene (Gene ID: 54503) in human. DHHC-13 is a multi-pass membrane protein that serves as a palmitoyl acyltransferase (PAT) specific for a subset of neuronal proteins, including HD and GAD2 and may play a role in the pathogenesis of Huntington disease (HD). It is reported to be dysfunctional in the presence of the HD mutation and HIP-14 deficient mice are shown to develop features of HD. DHHC-13 also plays a role in cellular magnesium homeostasis. It contains a DHHC domain (aa 426-476 in isoform 1 and 250-300 in isoform 2), which is required for its palmitoyltransferase activity. (Ref.: Young, FB et al. (2011). Prog. Neurobiol. 97(2); 220-238).

Specifications

• Antigen: ZDHHC13
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene Alias: Palmitoyltransferase ZDHHC13;EC: 2.3.1.22;Huntingtin-interacting protein 14-related protein;HIP14-related protein;Huntingtin-interacting protein HIP3RP;Putative MAPK-activating protein PM03;Putative NF-kappa-B-activating protein 209;Zinc finger DHHC domain-containing protein 13;DHHC-13
• Host Species: Mouse
• Purification Method: Protein G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Clone 26D1 detects human Palmitoyltransferase ZDHHC13. It targets an epitope within 111 amino acids from the N-terminal region of isoforms 1 and 2. This sequence is conserved in both isoforms.
• Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
• Isotype: IgG1 κ

• Applications: Western Blot
• Clone: 26D1
• Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
• Gene Symbols: ZDHHC13;HIP14L;HIP3RP
• Immunogen: MBP-tagged recombinant fragment corresponding to 111 amino acids from the N-terminal region of human Palmitoyltransferase ZDHHC13, isoform 2.
• Quantity: 100 μL
• Research Discipline: Neuroscience
• Gene ID (Entrez): NP_001001483
• Target Species: Human
• Form: Purified