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Invitrogen™ ZEB1 Polyclonal Antibody
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Catalog No. PIPA528221
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100 μL
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PIPA528221 100 μL
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Catalog No. PIPA528221 Supplier Invitrogen™ Supplier No. PA528221
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: HeLa, 293T, HepG2, MDA-MB-231, Neuro2A, NIH-3T3, C2C12, ZEB1 shRNA-transfected HeLa. Predicted reactivity: Mouse (91%), Rat (89%), Chicken (90%), Bovine (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

ZEB1 (Zinc finger E-box-binding homeobox 1) acts as a transcriptional repressor. It inhibits interleukin-2 (IL-2) gene expression. ZEB1 enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and depending on the cell type. It represses E-cadherin promoters and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. ZEB1 also represses BCL6 transcription in the presence of the corepressor CTBP1. It postively regulates neuronal differentiation and represses RCOR1 transcription activation during neurogenesis. Mutations in the gene can result in corneal dystrophy, posterior polymorphous and corneal dystrophy, Fuchs endothelial 6.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZEB1
Applications ChIP Assay, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.13 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol, 1% BSA and 0.025% ProClin 300; pH 7
Gene ZEB1
Gene Accession No. P37275, Q64318
Gene Alias [delta]EF1; 3110032K11Rik; AREB6; BZP; Delta EF1; delta-crystallin enhancer binding factor 1; deltaEF1; DELTA-EF1; FECD6; LOW QUALITY PROTEIN: zinc finger E-box-binding homeobox 1; MEB1; MGC133261; Negative regulator of IL2; Nil2; NIL2A; NIL-2A; NIL-2-A; NIL-2-A zinc finger protein; OTTHUMP00000019405; posterior polymorphous corneal dystrophy 3; PPCD3; RP11-472N13.4; Tcf18; TCF8; TCF-8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); Tw; twirler; ZEB; Zeb1; Zfhep; Zfhx1a; Zfx1a; Zfx1ha; zinc finger E-box binding homeobox 1; zinc finger E-box-binding homeobox 1; Zinc finger homeobox protein 1a; zinc finger homeodomain enhancer-binding protein
Gene Symbols ZEB1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human ZEB1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21417, 6935
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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